Neuro-Diversity, Metabolism, Diet and the Need for Precision Medicine

So to me the important thing about "Maternal Immune Activation" is "DYSREGULATION" of MULTIPLE SYSTEMS OF THE BODY.

And one of the BIG KEYS to that is "MITOCHONDRIA."

Down Syndrome based on research from the University of Colorado School of Medicine is now being conceptualized as an IMMUNE DISORDER.  See also Mayo Clinic on general Down Syndrome information.

Nobody is expecting Down Syndrome to be REVERSED by "DIET" alone.

High IQ Developmental Difference/Disorder --- the reality of that is not something we're really willing to accept.   I'm not saying we should "ACCEPT IT and DO NOTHING" ---

• But there can be much more of looking for a "QUICK FIX" --- that may in fact help --- may even be LIFE SAVING
• Even as the Developmental Aspects are shrugged off, ignored or never appreciated in the first place.
  

October 25, 2023

Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression

Maternal Inflammation During Pregnancy and Offspring Brain Development:

The Role of Mitochondria

"The association between maternal immune activation (MIA) during pregnancy and risk for offspring neuropsychiatric disorders has been increasingly recognized over the past several years. "

Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders (2021)

 Affiliations

•     Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment & Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, Hunan, 421001, People's Republic of China; Lhasa Guangsheng Hospital, Lhasa, People's Republic of China.
  

Translational Neuroscience: 
Toward New Therapies
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Chapter 3
Psychotic Disorders and the Neurodevelopmental Continuum

Michael J. Owen

"EMBO" stands for Excellence in the Life Sciences in Europe and Around the World

Metabolic Mind:  Interview with Dr. Chris Palmer at Harvard.

One of the current big ideas in PSYCHIATRIC DISORDERS is around METABOLISM and a KETOGENIC DIET.

This is being promoted by a number of academics and organizations including METABOLIC MIND.

Above is an interview with Dr. Chris Palmer at Harvard.  I find SOME of Dr. Palmer's ideas very interesting --- I am concerned that there is not an appreciation of some of the DEVELOPMENTAL ASPECTS of this.

Mental Illness & Metabolism

What are the basic rules for keto?

Keto basics

"The ketogenic diet is a very low carb, high fat diet that shares many similarities with the Atkins and low carb diets.

"It involves drastically reducing carbohydrate intake and replacing it with fat. This reduction in carbs puts your body into a metabolic state called ketosis.

"When this happens, your body becomes incredibly efficient at burning fat for energy. It also turns fat into ketones in the liver, which can supply energy for the brain (6Trusted Source).

"Ketogenic diets can cause significant reductions in blood sugar and insulin levels. This, along with the increased ketones, has some health benefits."

See Also:

The Endocrine System

How does the Microbiome Connect to the Brain, the Endocrine System & the Immune System

Physical Health Issues, the Immune System & Mental Health

Systematic review of mitochondrial genetic variation in attention-deficit/hyperactivity disorder (2022)


"These studies all reported on mitochondrial genetic variation in ADHD cases such as increased copy number, single-nucleotide polymorphisms, and haplogroup associations.

"This initial review of the experimental literature suggests mitochondrial genetic variation, in both the mitochondrial DNA and nuclear-encoded mitochondrial genes, may indeed contribute to ADHD pathophysiology.

"The studies reviewed here provide promising evidence for future research to further examine the mitochondrial genetics contributing to ADHD pathophysiology.

"We suggest that expansion of investigations into mitochondrial mechanisms may have potential to inform new treatment options for ADHD."

Immune synaptopathies: how maternal immune activation impacts synaptic function during development (2023)