Mental Illness & Metabolism
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Making sense of gut feelings in the traumatic brain injury pathogenesis. Royes LFF, Gomez-Pinilla F. Neurosci Biobehav Rev. 2019 Jul;102:345-361. doi: 10.1016/j.neubiorev.2019.05.012. Epub 2019 May 16.PMID: 31102601 Free PMC article. Review. An increasing number of clinical reports are alarming to show that metabolic dysfunction is associated with incidence of long-term neurological and psychiatric disorders. The autonomic nervous system, associated hypothalamic-pituitary axis, and the … Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder. Chan KL, Cathomas F, Russo SJ. Physiology (Bethesda). 2019 Mar 1;34(2):123-133. doi: 10.1152/physiol.00047.2018.PMID: 30724127 Free PMC article. Review. Metabolic syndrome and major depression are two of the most common and debilitating disorders worldwide, occurring with significant rates of comorbidity. ...Although far from conclusive, emerging evidence suggests that inflammation in the central and peripher … Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Goldstein JM, Holsen L, Huang G, Hammond BD, James-Todd T, Cherkerzian S, Hale TM, Handa RJ. Dialogues Clin Neurosci. 2016 Dec;18(4):425-436.PMID: 28179814 Free PMC article. Review. Major depressive disorder (MDD) is the number one cause of disability worldwide and is comorbid with many chronic diseases, including obesity/metabolic syndrome (MetS). ...On the basis of clinical and preclinical studies, we argue that prenatal maternal stress (ie, … |
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Nov. 2019
Youtube Description below: Stockholm Psychiatry Lectures, Nov 4, 2019 at Karolinska Institutet. "The Psychiatric-Metabolic Syndrome: How Stress and Trauma Program the Body and Brain" Professor Audrey Tyrka --- Dr. Tyrka's (Brown University, United States) research program is focused on the biological mechanisms of risk resulting from early stress and trauma in maltreated children and adults with a history of childhood adversity. She has made important contributions to understanding the metabolic, genetic, and epigenetic mechanisms of risk. Dr. Tyrka's research is focused on understanding the link between childhood trauma and physical and psychiatric illnesses. In addition to psychiatric disorders, including major depression and post-traumatic stress disorder (PTSD), stress and trauma increase risk for medical conditions such as obesity, diabetes and heart disease. Dr. Tyrka studies maltreated children and adults with early adversity to understand the metabolic, neuroendocrine, neuroimmune, and cellular aging pathways of risk for mood and anxiety disorders and related health conditions. The goal of this work is to elucidate the biology of risk and protection in order to inform prevention and treatment efforts. A second line of research involves efforts to advance the treatment of major depression. Our group has investigated several new treatments for depression, including novel pharmacologic and neurostimulation approaches to the treatment of major depression and treatment resistant depression. |