Scientific American
Head Injury May Cause Mental Illness (2014)
A Single Blow To The Head May Increase the Risk of Subsequently Developing a Disorder
https://www.scientificamerican.com/article/head-injury-may-cause-mental-illness/
Neuroimmunology & TBI
Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift (2017)
Abstract Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and diversity in the pathogenesis and extent of injury contribute to differences in the course and outcome of TBI. Following the primary injury, extensive and lasting damage is sustained through a complex cascade of events referred to as "secondary injury." Neuroinflammation is proposed as an important manipulable aspect of secondary injury in animal and human studies. Because neuroinflammation can be detrimental or beneficial, before developing immunomodulatory therapies, it is necessary to better understand the timing and complexity of the immune responses that follow TBI. With a rapidly increasing body of literature, there is a need for a clear summary of TBI neuroimmunology. This review presents our current understanding of the immune response to TBI in a chronological and compartment-based manner, highlighting early changes in gene expression and initial signaling pathways that lead to activation of innate and adaptive immunity. Based on recent advances in our understanding of innate immune cell activation, we propose a new paradigm to study innate immune cells following TBI that moves away from the existing M1/M2 classification of activation states toward a stimulus- and disease-specific understanding of polarization state based on transcriptomic and proteomic profiling. |
Brain Injury,
The Immune System, the endocrine system & Mental Health
|
An Unhappy Triad: Brain Injury, Mental Illness and Addiction --
" Dr. Garnet Cummings is the Executive Director of Brain Care Centre in Edmonton, Alberta. He was the Chief of Emergency at the Royal Alexandra Hospital until an accident left him with a brain injury. "Here he discusses the “unhappy triad” of brain injury, mental illness and addiction. "To view the full webinar, go to https://www.youtube.com/watch?v=SR7WS... " |
|
Jonathan Godbout, professor of neuroscience at The Ohio State University Wexner Medical Center, specializes in how the immune system and the brain communicate and how that communication changes with brain injury, brain aging, or psychological stress. Here, he briefly describes how brain injuries can cause inflammation that may appear later.
Loma Linda University Health (2021)
Discusses the problem of INFLAMMATION in the context of BRAIN INJURY and possible treatment.
Discusses the problem of INFLAMMATION in the context of BRAIN INJURY and possible treatment.