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Mitochondrial DNA CoPy Number in Neuro-Developmental & Psychiatric Disorders -----Cellular Aging

6/13/2024

Val's Take

Mitochondrial DNA plays a role in many chronic illnesses.
It is less clear if Mitochondrial DNA Copy Number can serve as a biomarker in any or some of these chronic diseases.
Many researchers are devoted to addressing these questions throughout medicine, including neuro-developmental and psychiatric disorders, cardio-vascular issues, auto-immune issues, cancer, etc.
Additionally, many of these other illnesses and disorders can have psychiatric symptoms and neuro-developmental and psychiatric disorders often do involve some aspect of fatigue.

Telomere length and mitochondrial DNA copy number in bipolar disorder: identification of a subgroup of young individuals with accelerated cellular aging (2022)

Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis (2023)

Mitochondrial DNA copy number in autism spectrum disorder and attention deficit hyperactivity disorder: a systematic review and meta-analysis (2023)

Leukocyte mitochondrial DNA copy number in schizophrenia (2020)

Cells dispose of cytoplasmic mitochondrial DNA by nucleoid-phagy (May 2024)

Mitochondrial damage in stress conditions results in the release of mitochondrial DNA (mtDNA), causing inflammation that is linked to various diseases.

We discovered a mechanism for the elimination of this harmful mtDNA — ‘nucleoid-phagy’.

Targeting this process represents another way to treat mitochondrial damage-related diseases.

Inflammation and mitophagy are mitochondrial checkpoints to aging (April 2024)

Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation.

Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

Faulty DNA disposal system causes inflammation (Feb. 2024)

"Salk scientists outline mouse cell inflammation pathway from mitochondrial stress to leaking endosomes to immune system initiation, revealing new potential therapeutic targets to reduce inflammation in aging and disease."

Mitochondrial DNA Copy Number as a Biomarker of Multiple Sclerosis (2023)

Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study (2010)

Connecting the Dots: Maternal immune activation, Neuro-Developmental Disorders and Chronic Disease

6/11/2024

Val's Take: We are connecting the dots among Neuro-Diverse "categories" --- we're also connecting the dots of Chronic Disease including autoimmune disorders and cancer with Neuro-Diversity.

JAMA: More Evidence Linking Autoimmune Diseases to ADHD (2021)
The evidence for bidirectional links between the immune system and the central nervous system has accumulated over the last few decades.

Down Syndrome Is an Immune Disorder (2018)
Researchers from the University of Colorado School of Medicine are conducting breakthrough research indicating that Down syndrome could be considered a disorder of the immune system. The findings announced in the journals eLife and Scientific Reports are a significant development in understanding Down syndrome.

Immune synaptopathies: how maternal immune activation impacts synaptic function during development (2023)

Genomic Medicine: Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome (2023)
Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs) are more prone to develop certain types of cancer. Notably, however, the case statistics can be impacted by late discovery of cancer in individuals afflicted with NDDs, such as intellectual disorders, autism, and schizophrenia, which may bias the numbers.

Kings College London
Thinking Twice About ADHD & Autism Spectrum Disorder

Ehlers Danlos Society / Jane Green
2023 Connecting The Dots between Autism, ADHD, Dyspraxia and EDS (Ehlers Danlos Syndromes) and HSD (Hypermobility Spectrum Disorders)

Selective Timing of Maternal Immune Activation Alters Developmental Milestones, Behavior, and Blood-Brain Barrier Integrity (May 2024)

***Physical Health Issues, the Immune System & Mental Health Index

Science Up

New Science Is Amazing and It has Huge Moral Implications NOW

Mental Health Is going to have to change a whole lot to be effective --- a big part of that is appreciating the large role of the immune system in mental & brain disorders

Translational Medicine Friday

We're riffing off NPR's Science Friday to create Translational Medicine Friday.

We'll be collecting Research Article recommendations for Clinicians with regard to Cognitive Disability.

There is much in the RESEARCH JOURNALS and we'll just be SKIMMING THE SURFACE.

The POINT is to INCREASE FUNDING for TRANSLATIONAL RESEARCH at the Federal Level for the National Institutes of Health, the Centers for Disease Control, the Nation's Research & Teaching Hospitals and possible collaborations with Medicare and Medicaid providers.

Translational Medicine Friday

Mitochondrial DNA CoPy Number in Neuro-Developmental & Psychiatric Disorders -----Cellular Aging

Connecting the Dots: Maternal immune activation, Neuro-Developmental Disorders and Chronic Disease

Translational Medicine Friday

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