Val's Blog 2

Paradigm shifts: The Discovery is just the beginning

7/4/2025

The Copernican Revolution, the Darwinian revolution & the developmental origins of health and Disease

Val's Take/Conjecture

Things have "EVOLVED" a lot for PSYCHIATRY in the past 10 to 15 years on the RESEARCH LEVEL.
- It really started in 2013 with the National Institute of Mental Health saying the DSM 5 was scientifically invalid.
- Further Researchers around the world found problems with the DSM 5.

Part of the research was beginning to show that Bipolar Disorder was a MULTI-SYSTEM DISORDER.

Can bipolar disorder be viewed as a multi-system inflammatory disease? (2012)

According to Google AI, the roots of Immuno-Psychiatry could be traced to the late 19th Century and early 20th Century.

It is really in the 21st century that Immuno-Psychiatry and Neuro-Immunology have taken off.

The Immunology Podcast
Neuroimmunology & Behavior (2021)
Dr. Michael Burton, PhD -- Univ. of Texas

Big Think -- Robert Sapolsky
Why You Don't Have Free Will

With Stanford Professor Robert Sapolsky and "The Biology of Humans at Our Best and Worst" (2017)

Sapolsky did a master academic's documentation of his premise -- which is the Biological Basis of Behavior
Further, Sapolsky believes these concerns necessitate reform of the Criminal Justice System and I do too.
I haven't jumped on Sapolsky's "Anti-Free Will Bandwagon" mainly because it seems like John Bunyan's "Slough of Despond."

How Many Angels Can Dance on the Head of a Pin --
and the Free Will vs. Determinism Debate

TRYING TO GET --
THE "GIST OF IT"

The Grateful Dead
Touch of Grey

Val's Take:

A few things:

"We'll Get By, We'll Survive" --- or at least as Humanity --- we'll survive.
For those of us who have had a view of "mental health treatment" over the last 50 years---
- It's Concerning
There have been improvements.

Are current mental health professionals competent to handle Developmental Neuro-Immune Disorders affecting multiple systems of the body.

Well, not now. They could become competent.
Is this "EARLY DAYS" ---- yeah, but many researchers around the world are corroborating these new paradigms.
Further, my argument is really this is a lot more complicated than we're treating it.

On top of all this, we've got:

Maternal Immune Activation
The Neuro-Developmental / Psychiatric Continuum
The Developmental Basis of Health & Disease
Dysregulation of various glial cells, including microglia and astrocytes
Dysfunctional mitochondria
Epigenetic Changes
Etc.

We need Neuro-Immunologists and we need advances in Immuno-Modulatory Treatments.

We need that a lot more than we need the Status Quo.

With respect to the Copernican Revolution and the Darwinian Revolution, they greatly implicated religious beliefs.

Mental Health for various reasons often serves as a kind of SECULAR RELIGION.

When a PARADIGM SHIFT comes, there's a lot of work to both "DISMANTLE" and "RE-CONSTRUCT" the vast intellectual framework which will ultimately be "MODIFIED" by such a shift.

With regard to Neuro-Developmental and Psychiatric Disorders, there is irony that these PARADIGM SHIFTS will require considerable BRAIN ENERGY.

Frank Capra, "Manic Depression," and "It's a wonderful LIfe"

6/14/2025

Val's Take/Conjecture

I had generally viewed "It's A Wonderful Life" as a feel good, sweet movie --- and it is.
It was only after learning that Frank Capra had "Manic Depression" or Bipolar Disorder (or was thought to) --- that I started to appreciate how much "It's A Wonderful Life" is about mental illness.

One of the most affecting scenes is an out of control bullying George Bailey --- shaking the forgetful Uncle Billy.

Mr. Gower, Potter, Violet, Mary and even George's mother all have their issues.

Addressing lower level executive functioning issues (and fatigue) --- has the potential to make all of this a lot more manageable.

What we don't want is people defaulting to "AGGRESSION" to access the ENERGY they need.

Executive dysfunction, violence and aggression (2020)

Frank Capra --- 1897 - 1991

It's A Wonderful LIfe (1946)

One of the things that is so interesting about this portrayal of Uncle Billy --- he's not some wild and crazy guy --- he's a very nice guy with memory and executive functioning challenges.

One of the things we learn during the course of the movie --- if George hadn't been there, Uncle Billy would be in a mental institution.

Further, George has his problems and suicidality is one of them.

Executive Functioning Challenges as an Energy --- ATP Issue

Going from "I can't believe this" to "no wonder" ---The biological basis of behavior as a blessing

5/23/2025

Val's Take/Conjecture

Sapolsky's book "Behave: The Biology of our Best & Worst Selves" --- is really not just an argument for the Biological Basis of BAD Behavior --- but the Biological Basis of Behavior in both GOOD and BAD Behavior.

I think ultimately we will be able to accept as a GIVEN --- the biological basis of behavior.
- New Zealand in one government document appears to accept that.

The neurobiology of antisocial personality disorder (2024)

God of the Gaps, Criminal Liability of the Gaps

Moving On to the Biological Basis of Behavior as an Important Rationale for a public health approach to criminal justice

Robert Sapolsky
Free Will is Nothing but a Myth

I don't think "FREE WILL" is a myth -- BUT "FREE WILL" is not as all encompassing or absolute as we have often conceptualized it.

One of the problems that I have found with the "FREE WILL vs. Determinism" Debate is that IT IS RUNNING IN THE WRONG DIRECTION.

We're not starting out with absolute free will --- but we are gradually gaining more and more control.

One of the things that is particularly disconcerting is that we are still DISCOVERING our own biology. Gee, I thought we already knew that --- didn't you guys figure that out in the 18th Century --- No, Huh. . .

Former Director of the National Institute of Mental Health Thomas Insel tried to break this to us by saying we don't have a parts list for the brain --- This is an Age of Discovery.

Now some of those parts have been discovered since Insel made those statements over a decade ago (including over 3,000 different cell types in the brain)--- but the point is --- even in the 21st Century we're still figuring this out.

How Many Angels Can Dance on the Head of a Pin and the Free Will vs. Determinism Debate

IMPERFECTION and Faith, REASON & Empiricism

5/13/2025

Val's Take: There's a complicated relationship among FAITH, REASON & EMPIRICISM (SCIENCE). Further, it's not that one is perfect and the others aren't.

None of them are PERFECT, but that is why we need all three of them.

There is irony to understanding "the biological basis of behavior," the many, many moving parts, systems and bacteria we're still discovering.

Enya
Anywhere Is

The new pope Leo XIV came from the Augustine Order. St. Augustine was said to have inspired both the Medieval Scholastics and the Humanists.

His Confessions have led some to refer to him as "the BAD BOY of NORTH AFRICA."

Spirituality & Mental Illness

Ideas and the Need for Conversation & Dialogue

Even a dog distinguishes between being stumbled over and being kicked

Faith, Criminal Justice & Bringing Religion in from the Cold

How many angels can dance on the head of a pin and the free will vs. determinism debate

The Cognitive Errors of Modern American Society Intelligence, Sexuality, Energy & Equality

3/8/2025

Val's Take/Conjecture

I have talked about being PRO-LIFE because I think my own experiences and reading of the research would indicate that many if not most of us are COMPLICATED MIXED BAGS.
Further, people who are on some eugenics crusade or similar bandwagon --- tend to have their own neuro-developmental and/or psychiatric issues ---
- which are often related to Neuro-Developmental Inflammation

It "appears" that there may be a CATCH-22 when it comes to "INTELLIGENCE," "BIO- ENERGY," "EMOTIONAL REGULATION" and "INFLAMMATION" ----

affecting everyone who is "AGING" --- which is everyone and
prematurely affecting people with more Neuro-Developmental Inflammation.

Previously, we've viewed males as more subject to Neuro-Developmental Disorders and Women as more subject to Psychiatric Disorders.

What about that Neuro-Developmental/Psychiatric Continuum?
It's not that females can't be a safety risk, BUT males with:
- neuro-developmental and/or psychiatric disorders
- and/or brain injury and/or
- substance issues
- are more of a safety risk.

On the other hand, much of this can be traced to Maternal Immune Activation (even the Brain Injury which is often associated with ADHD).

Further, there is also Paternal Immune Activation, and
These biological issues often have Generational Histories.

Scientific Reality, A Kinder Gentler Nation & Coming to terms with the State of Nature

How Many Angels Can Dance on the Head of a Pin and the Free Will vs. Determinism Debate

The Definitional Argument in Mental Health & Criminal Justice Policy

Lateral Thinking & Conspiracy Theories

Pharrell Williams
Freedom

Pharrell Williams is presenting a sophisticated view of "Freedom" --- that sees the Universe made of the same things.

We do have amazing INTELLECTUAL POWER --- and we are NOT CLONES -- we're DIVERSE.

We're struggling to conceptualize LGBTQ+ (which is pretty diverse community in itself).

Google AI says that LGBTQ+ is not a neuro-developmental disorder --- but does say ---

LGBTQ+ is associated with "Autism." Hmmm . . .

Our neuro-developmental/psychiatric categories are messy and in the process of revision and being re-conceptualized in profound ways.

Further, there are significant sex differences between Males and Females --- and that can be expressed in tremendous diversity under Maternal Immune Activation.

Finally, I'm not really buying the idea that these intense human conflicts are between Neuro-Typical people and Neuro-Diverse people.

It seems to me that DIVERSE Neuro-Diverse Folks are well represented on all sides.

What's the Point?

We need to understand foundational biological issues better than what we actually do.

There are significant numbers of LGBTQ youth who are homeless.
- The society seems confused as to whether sexual identity and orientation are a life-style choice or biologically driven.
- We don't seem to have a common understanding of what we're talking about.

With respect to cognitive disability in Criminal Justice, we're uncertain about biological drivers of intent.

Somebody like me, I am persuaded by some algebraic argument involving the biological basis of behavior ---
But even I want as much specificity as possible with regard to that underlying biology.

Metabolic Psychiatry & a Significant Paradigm shift

4/27/2024

Val's Take

Metabolic Psychiatry is precipitating a paradigm shift.
I think in the next 5 years, maybe less --- the Mental Health System will be incorporating some aspects of Metabolic Psychiatry.
Particularly interesting is that metabolomic biomarkers have already been found for bipolar disorder and depression.
What happens if we find metabolomic biomarkers for anti-social personality disorder?
I always understood that a Public Health Approach to Criminal Justice was largely dependent on better understandings.
The National Institute of Mental Health (NIMH) took on the American Psychiatric Association and the DSM 5 --- but it was politically fraught. Further, there was no replacement for the DSM 5.
The Metabolic Mind folks, relying on research of large universities, are not afraid to take on the status quo.
Further, I think if Clinicians actually have access to the research --- I don't know that it will be that hard a sell.

I have followed the science on Neuro-Developmental Disorders and Psychiatric Disorders because I believed there did need to be major change in Mental Health practice.

That change isn't fully here --- but I think the foundation has been laid. All the questions haven't been answered but it feels like a huge step up from where we've been and profound understandings have been acquired.

WE NEED a "NaRRATIVE" that hangs together when it comes to the Neuro-developmental - Psychiatric ContinuumThat could vastly improve Public Policy & Justice

4/5/2024

Kurt Vonnegut --- "Cat's Cradle"

Val's Take/Conjecture

There is A LOT to weave together when it comes to understanding the Neuro-Developmental-Psychiatric Continuum and it's relationship to other disorders.
The DOMINANT PARADIGM of the last 60 years --- "JUST TAKE THE DAMN MEDICATION" --- probably averted some tragedies and created others.
When we see a bunch of people lying on the street --- one idea is that "THEY'RE JUST LAZY."
Another possibility is some of them have serious METABOLIC DISORDERS that involve the brain and it's ability to produce ATP to run not only the brain but the rest of the body, including the ENDOCRINE SYSTEM.

People subject to MATERNAL IMMUNE ACTIVATION during their own time in the womb tend to have "HYPER-CONNECTED BRAINS."
I would submit that "HYPER-CONNECTED BRAINS" require more ATP to operate.

One of the things that some studies are pondering are the GENERATIONAL ASPECTS to MATERNAL IMMUNE ACTIVATION.

We live in such an INDIVIDUALISTIC CULTURE that CONNECTIONS to the BROADER WORLD are often DENIED --- sometimes out of PRACTICALITY we don't have the BANDWIDTH to consider it.

BUT what this often looks like is a BIG MORAL JUDGMENT coming down on the INDIVIDUAL.

It's probably no accident that the DEADLIEST Psychiatric Disorders are EATING DISORDERS.

One of the challenges, probably not the only challenge, is to make KETOGENIC DIETS --- HEART HEALTHY.

We did go through a period of LOW FAT, HIGH SUGAR that was pretty DISASTROUS in the weight-loss market.

I think more and more people recognize the problem of sugar but CAFFIENATED DRINKS and ENERGY DRINKS --- that market is HUGE ---- and I would submit it is because many people don't have the ENERGY to get through the day and they are looking for a QUICK FIX.

The effect of caffeine is related to its structural similarity to adenosine. Adenosine is a nucleotide and is important for coding genes, but it is also used for energy in the form of ATP and as a neuromodulator and signaling molecule. When the brain is active, it consumes lots of ATP (adenosine triphosphate) as an energy source.

Reference: Caffeine: How it works and myths surrounding it - Chemistry ...

Sleep Foundation: Caffeine and Sleep

Key Takeaways
Caffeine promotes wakefulness by blocking adenosine, a sleep-inducing chemical.
Sensitivity to caffeine varies among individuals and depends on how often it is consumed.
Avoid caffeine at least 8 hours before bedtime to ensure better sleep quality.
Reduce your daily caffeine intake if you notice insomnia, anxiety, or headaches impacting your ability to sleep.

Unfortunately, even DIET SODAS are bad for our TEETH and if it's BAD for our TEETH --- it's generally bad for our PHYSICAL & MENTAL HEALTH.

I have started to include MORE FAT in my diet and the effects were pretty DRAMATIC --- I seemed to not only need less LITHIUM, but also LESS DIET COKE.

I think if people have HEALTHY WAYS to MANAGE their BIOLOGY --- They'll DO IT.

BUT TRUTH is the Medical Professional has been all over the map the past few decades regarding diet advice and some of it was TRULY CATASTROPHICALLY UNHEALTHY.

AND for those people who DON'T LOOK LIKE they have SPECIAL NEEDS --- BUT DO ---

YOU MY FRIEND ARE AT VERY HIGH RISK.

Wilma Mankiller --- 1st Female Chief of the Cherokee Nation

Transgenerational Effects of Maternal Immune Activation on Specific Antibody Responses in Layer Chickens.

Verwoolde MB, Arts J, Jansen CA, Parmentier HK, Lammers A. Front Vet Sci. 2022 Feb 17;9:832130. doi: 10.3389/fvets.2022.832130. eCollection 2022. PMID: 35252424 Free PMC article.

Activation of the maternal immune system may affect innate and adaptive immune responses in the next generation and may therefore have implications for vaccine efficacy and dietary immune modulation by feed additives. ...Furthermore, our …

Maternal immune activation transgenerationally modulates maternal care and offspring depression-like behavior.

Ronovsky M, Berger S, Zambon A, Reisinger SN, Horvath O, Pollak A, Lindtner C, Berger A, Pollak DD. Brain Behav Immun. 2017 Jul;63:127-136. doi: 10.1016/j.bbi.2016.10.016. Epub 2016 Oct 17. PMID: 27765645 Free article.

Gestational infection is increasingly being recognized for its involvement as causative mechanism in severe developmental brain abnormalities and its contribution to the pathogenesis of psychopathologies later in life. First observations in the widely accepted maternal …

Transgenerational Sex-dependent Disruption of Dopamine Function Induced by Maternal Immune Activation.

Santoni M, Frau R, Pistis M. Front Pharmacol. 2022 Feb 8;13:821498. doi: 10.3389/fphar.2022.821498. eCollection 2022. PMID: 35211019 Free PMC article.

Mounting evidence supports the hypothesis that detrimental effects of maternal immune activation might be transmitted across generations. ...These results confirm that maternal immune activation negatively influences, in a sex-depe …

At the end of the day, WE DON'T HAVE THIS FIGURED OUT we're figuring it out.

That matters when it comes to JUSTICE and BURDEN of PROOF

Burden of Proof

A mental Health Profession that doesn't want to treat people with "developmental Disabilities" and criminal Justice

12/11/2023

Conjecture

I am gonna continue my bitching about the Mental Health Profession in this but I'm gonna include Legal --- Criminal Justice as well and maybe some other aspects of "STREET LAW."

I don't think "DISABILITY LAW" is where it needs to be when it comes to "COGNITIVE DISABILITY" --

but I think it is generally closer to "REALITY" than a lot of what we're doing.
And in the last 10 years, Disability Law has slowly recognized that many of the highest need people they are trying to advocate for are actually in the Criminal Justice System.

The Mental Health Profession --- OMG!

Once you realize that most people in the mental health profession don't want to work with people with "developmental disabilities"
- You realize what a nightmare scenario this can be.

Further, these "developmental issues" are coming in the context of "SENSORY PROCESSING" and literally CELLULAR "REACTIVITY"
- not necessarily in a lower IQ.

BUT if we're EQUATING EXECUTIVE FUNCTIONING with IQ that is likely to do MORE HARM THAN GOOD.

In fact --- IQ or some type of Special Ability or Special Interest --- may be HIGHER THAN THE NORM.

I think this is also a CLUE as to why we have really struggled to define INTELLIGENCE ---
- I think it can come wrapped in some idiosyncratic SENSORY PROCESSING.

This Has Some IMPLICATIONS for our CURRENT INTELLECTUAL LIMITS

a lot of who we study in school are neuro-diverse people who had some big strengths and some surprizing challenges.
trying NOT to ROMANTICIZE that is important
HIERARCHY doesn't really work that well to manage the strengths and challenges of almost 8 BILLION PEOPLE.

I'm NOT A TRUE BELIEVER in Mental Health's "PRO-SOCIAL COMPETENCY" Religion

--- even though I consider myself extremely "PRO-SOCIAL."

CRIMINAL LAW but also FAMILY LAW ---

has been experimenting with some DIFFERENT MODELS
- Problem-Solving Courts
- Collaborative Law
We're needing to add to these models a PUBLIC HEALTH APPROACH that is EVOLVING ---
- and may not be what we have traditionally thought in this area.

The Limits of Neuro-Plasticity (2010) by Neuro-Skeptic

Val's Note: I'm NOT SKEPTICAL over the Long Term that we will ultimately be able to surpass some if not all of these limits.

And PROGRESS IS BEING MADE.

BUT we're not there yet in many cases, but we're often PRETENDING we are.

Psychiatry & the Criminal Justice System: Simplicity on the Near Side of Complexity

3 Big Takeaways from the Research

This is the BIG KAHUNA --- Neuro-Diversity is a big source of "Mental Illness"

New Understandings Matter

The Biological Basis of Behavior: The Slow Process of Coming to Terms

11/2/2022

Conjecture

I think a BIG THEME in Human History right now is COMING TO TERMS WITH SOME RELATIVELY DIFFICULT LIMITS in COMPLEX NATURAL PROCESSES that we ---

WEREN'T AWARE OF --- or
DIDN'T REALLY UNDERSTAND
- and that "UNDERSTANDING" is in the best of times generally RELATIVE
AND "UNDERSTANDING" requires coming to terms with:
- SOME BIG COSTS
- RE-ALLOCATING RESOURCES

On the ENVIRONMENT SIDE we're coming to terms with CLIMATE CHANGE.

On the BIOLOGICAL SIDE we are slowing coming to terms with the GUT-IMMUNE-BRAIN TRIAD.
- Human Behavior was already complicated.
- It's a lot more complicated than we thought.

The "BIG LIE" or "IGNORANCE" in MODERN SOCIETY has been that nothing is connected ----
- and that we're on TOP OF THIS---
  - WE'RE NOT.

In the Legal System --- this is about one isolated BAD ACT and BAD INTENT ----
- to see more integrated and complicated patterns, including HISTORICAL issues ---
  - That include Genocide, Slavery, Jim Crow as well as a move away from Traditional Farming Practices, Plastics in our bodies, etc.---

We don't have the "SYSTEMS" to deal with that --- NOT ON THE SCALE NEEDED.

It is very hard to go 10 feet in this Society without running into some PROFOUND TRAUMA --- even if you "INDIVIDUALLY" didn't suffer CHILDHOOD TRAUMA or have ADULT PTSD.

Further, SECONDARY TRAUMA is an issue for many people PERSONALLY and PROFESSIONALLY and BIOLOGICALLY.

Trauma, Toxins, Maternal Immune Activation, Auto-Immune Diseases, Cancer, Long-Haul COVID --- all of these can have PSYCHIATRIC RAMIFICATIONS.

Physical BOUNDARIES / Emotional BOUNDARIES can be important --- But they often are a "TEMPORARY FIX" ---If we don't deal with the UNDERLYING ISSUES -- things tend to get worse.

Image Credit: European Society for Translational Medicine

We need to invest more in TRANSLATIONAL RESEARCH and MEDICINE regarding the BRAIN-IMMUNE-GUT (Endocrine, Metabolism) CONNECTION to Behavior---

Further, TRANSLATIONAL CRIMINAL JUSTICE APPLICATIONS are NEEDED NOW.

The Center for Evidence-Based Crime Policy at George Mason University

New understandings regarding relationships between Neuro-developmental Disorders, Psychiatric Disorders & Neuro-Inflammatory biomarkers should be transformative

11/1/2022

New Genetic Evidence Suggests a Continuum Among Neurodevelopmental and Psychiatric Disorders

The understanding that Neurodiversity/Neuro-Developmental Differences or Disorders are underlying many psychiatric complaints SHOULD BE TRANSFORMATIVE.
It is very much about getting out of the PERSONALITY DISORDER grab bag of problematic behaviors ---
- Which is problematic for women, and
- It is especially problematic for men in Criminal Justice.
While at the same time hopefully getting out of LATE DIAGNOSIS of people who have become adept at MASKING and whose STRENGTHS have been recognized at least on some level.
- Even if some of us somehow escaped a personality disorder diagnosis.
- All was not well --- and clinicians were often ill prepared to recognize or address DEVELOPMENTAL DIFFERENCES/DISORDERS.
  - THIS IS ONE OF THE BIG REASONS WHY WE ARE NOT GETTING ON TOP OF OUR MENTAL HEALTH CRISIS.

ICERN Web Library of Neuropsychiatry

ICERN: International Centre for Research & Education in Neuropsychiatry

Focusing on novel neuroinflammatory biomarkers and targets in understanding and managing suicide

BIOMARKERS as they slowly become available I think will reveal a quite COMPLICATED SOCIETY ---

Whose SUBJECTIVE JUDGMENTS are SUSPECT.
Further, the UNCONSCIOUS BIAS behind them and the "REASONABLENESS" of the Majority represent their own kind of PERNICIOUS TYRANNY.
- I'm not against "REASONABLENESS" -- but failing to appreciate DEVELOPMENTAL DIFFERENCES is NOT REASONABLE.

Unconscious Bias

<<Previous

Paradigm shifts: The Discovery is just the beginning

The Copernican Revolution, the Darwinian revolution & the developmental origins of health and Disease

Frank Capra, "Manic Depression," and "It's a wonderful LIfe"

Going from "I can't believe this" to "no wonder" ---The biological basis of behavior as a blessing

IMPERFECTION and Faith, REASON & Empiricism

The Cognitive Errors of Modern American Society Intelligence, Sexuality, Energy & Equality

Metabolic Psychiatry & a Significant Paradigm shift

WE NEED a "NaRRATIVE" that hangs together when it comes to the Neuro-developmental - Psychiatric ContinuumThat could vastly improve Public Policy & Justice

A mental Health Profession that doesn't want to treat people with "developmental Disabilities" and criminal Justice

The Biological Basis of Behavior: The Slow Process of Coming to Terms

New understandings regarding relationships between Neuro-developmental Disorders, Psychiatric Disorders & Neuro-Inflammatory biomarkers should be transformative

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VAL'S BLOG 2

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