The Eggshell Skull Rule and Environmental Toxins

What are the implications of the "Eggshell Skull Rule" and the "Exposome" for Neuro-Diverse people with Maternal Immune Activation?

Val's Take/Conjecture

• Maternal Immune Activation does seem to create idiosyncratic vulnerabilities, including types of immuno-compromised systems.

 

• There are man-made toxins and natural toxins.

​PESTICIDES

• Immuno-compromised people are more vulnerable to Pesticides than people who are not immuno-compromised.
  • Pesticides are also associated with increased risk of Parkinson's.
  • Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders (2024)  

​MICROPLASTICS

• Impacts of microplastics on immunity (2022)

Environmental Toxins & Mental Health

Previously we've conceptualized Neuro-Developmental, Psychiatric and Neuro-Degenerative Disorders as having to do with the Brain and Neurons.

More and more we are conceptualizing these disorders as NEURO-IMMUNE DISORDERS, and there are more components than that.

BUT the Immune System is a critical system --- and we can't understand these disorders without understanding the Immune Component.

​THE EXPOSOME ACROSS THE LIFESPAN & TRANS-GENERATIONAL IMPLICATIONS

• ​"The exposome concept refers to the totality of exposures from a variety of external and internal sources including chemical agents, biological agents, or radiation, from conception onward, over a complete lifetime.
• "It encompasses also 'psychosocial components' including the impact of social relations and socio-economic position on health."

EGGSHELL SKULL RULE

The eggshell skull rule, also known as the thin skull rule, is a common law doctrine that makes a defendant liable for the plaintiff's unforeseeable and uncommon reactions to the defendant's negligent or intentional tort .

If the defendant commits a tort against the plaintiff without a complete defense , the defendant becomes liable for any injury that is magnified by the plaintiff's peculiar characteristics.

It is essential to emphasize that the eggshell skull doctrine does not entitle the plaintiff to compensation for an unrelated pre-existing injury.

​A common example of this doctrine is that a person's skull was very thin due to the person’s own health condition, if the person gets into an accident, the other person who caused the accident will be liable for the actual damages , although the average person would not suffer the same serious injuries in the same accident as the person with the thin skull.

​Late prenatal immune activation in mice induces transgenerational effects via the maternal and paternal lineages (2023)