One of the big psychological challenges in Modern Times is Illness that is not completely understood now, and yet the expectation is that treatments or cures will be available in the future.

​For People with Neuro-Developmental / Psychiatric Disorders and an IQ over 70 --- outdated conceptualizations put many at risk of homelessness and/or incarceration.​

Further, the needs and types of support needed are often different than what is being provided.

Updated paradigms have the real possibility of directly addressing underlying Developmental processes and subsequent inflammatory exposures that may be magnified by dysregulated microglia, etc.

Val's Take/Conjecture

• One of the big discoveries of the 21st Century is that NEURO-DEVELOPMENTAL & PSYCHIATRIC DISORDERS involve MULTIPLE SYSTEMS OF THE BODY.
• That does include the Brain and the Central Nervous System (CNS).
• It also includes the Immune System, the Microbiome and the Endocrine System.

​Role of the immune-kynurenine pathway in treatment-resistant schizophrenia.  (2024)

​Is depression the missing link between inflammatory mediators and cancer?  (2022)

Three major routes to depression in cancer in which proinflammatory mediators are implicated, seem likely.

Activation of the kynurenine pathway involving cytokines, increases tryptophan catabolism, resulting in diminished levels of serotonin which is widely acknowle …

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• Transgenerational Epigenetic Inheritance was discovered by Alexander Brink in 1956 as it relates to maize.
• Since then Epigenetics has been identified as a Key Component of our most difficult chronic diseases, including:
  • Autoimmune Diseases
  • Cancer
  • Type 2 Diabetes
  • Neuro-Developmental Disorders, and
  • Psychiatric Disorders

Val's Take/Conjecture

• One of the big discoveries of the 21st Century is that NEURO-DEVELOPMENTAL & PSYCHIATRIC DISORDERS involve MULTIPLE SYSTEMS OF THE BODY.
• That does include the Brain and the Central Nervous System (CNS).
• It also includes the Immune System, the Microbiome and the Endocrine System.

​Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders (2023)

​How Inflammation Affects the Brain in Depression (2021)

While it is unclear how the inflammatory response affects brain networks involved in the psychopathology of depression, it has been suggested that proinflammatory cytokines and several metabolites from inflammatory processes in the central nervous system (CNS) exert direct neurotoxic effects on the brain. 

These effects may lead to dysfunction of the neural circuits involved in emotion regulation and reward or cognitive processing, which is associated with overwhelming low mood, failure of...

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​Society of Biological Psychiatry

Dysfunction of Kynurenic Acid in Major Psychiatric Diseases

​This will focus largely on the contexts of:

• Maternal Immune Activation
• and Exposure to Endocrine-Disrupting Chemicals

2nd Draft:  More References with regard to Endocrine Disruptors and Neuro-Developmental & Psychiatric Disorders.