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Building Individualized Supports For People with Neuro-Developmental Disorders & An IQ Over 70

1/26/2025

Additionally, neuro-diverse kids, adolescents and adults are more different from one another than neuro-typical folks are different from one other.

When I use the term neurotypical, I generally mean someone who did not experience Maternal Immune Activation (MIA).

Further, the HOPE that DEVELOPMENTAL DISORDERS really had negligible effects if you had an IQ over 70 is not reality, and more and more researchers and clinicians recognize that.

Part of the issue has been that when we thought of DEVELOPMENTAL DISORDERS we often thought of INTELLECTUAL DISABILITIES.

We weren't necessarily thinking of people with average or high intelligence and HIGHLY DYSYSREGULATED SYSTEMS of the body that would greatly impact EMOTIONAL REGULATION, and other health issues including CANCER.

Interaction between maternal immune activation and postpartum immune stress in neuropsychiatric phenotypes (2024)

"Maternal immune activation (MIA) during pregnancy alters the offspring’s immune profile as well as their neurodevelopmental trajectories, thereby increasing the risk of neuropsychiatric disorders, including intellectual disability, autism spectrum disorder (ASD), schizophrenia, and bipolar disorder."

Neurodevelopmental disorders, immunity, and cancer are connected (2022)

Why is michael Marshall dead?

1/21/2025

Val's Take: Denver has made historic progress in providing housing and coordinating with Medicaid case management to substantively address homelessness in the city.

Credit goes to Mayor Mike Johnston in the first instance --- and then there are all those homeless advocates and people with lived experience of homelessness.

Other American cities such as Houston and even other countries such as Finland have also made great strides in addressing homelessness and served as models for Denver.

Colorado State Government understands the need to build out a CONTINUUM OF CARE --- they are unsure how they will pay for it. Better understanding who really needs the HIGHEST LEVELS in the CONTINUUM of CARE could help.

Michael Marshall may not have needed that highest level of care and he might be alive today if he had access to secure housing and adequate case management.

MLK Day Marade 2016
Why is Michael Marshall Dead?

The Cellular basis of Neuro-Developmental & Psychiatric Disorders

1/20/2025

Val's Take/Conjecture

The pace of research seems to be "quickening."
It is likely 2025 will bring more in solidifying a biological understanding of neuro-developmental and psychiatric disorders.
There has been a skepticism in the public regarding mental illness without more precise information.
Even prior to the Grand Understandings and Treatments --- I think the public will be more likely to support Therapeutic Custodial Care over Incarceration if there is a firmer understanding of the biological issues.
Many advocates would have been concerned about this BRAVE NEW BIOLOGICAL understanding of psychiatric disorders.
Further, we should be vigilant.
Of course, the frightening limitations of our current understandings have made some of us ready for something different and better.

BIOLOGICAL PSYCHIATRY and "LIFESTYLE PSYCHIATRY"

Theoretically, there is no conflict between Biological Psychiatry and Lifestyle Psychiatry.
I do think addressing Lifestyle issues can help and even greatly improve Neuro-Developmental & Psychiatric Disorders --- and we should be doing that.
The concern that I have with "Lifestyle Psychiatry" is it often doesn't seem to appreciate that Neuro-Developmental & Psychiatric Disorders are largely DEVELOPMENTAL and begin IN UTERO.
Further, I do think there is a need to work one's way back in the CHAIN OF CAUSALITY --- because a lot of these problematic "LIFESTYLE CHOICES" are actually being driven by some problematic biology.

Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics (2024)

"We observe and replicate cell-type compositional shifts for

Alzheimer's disease (endothelial cell loss),

autism (increased microglia), and

schizophrenia (decreased oligodendrocytes), and

find age- and sex-related changes."

The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning (2024)

"Our cumulative results suggest that prelimbic TREM2-mediated excessive microglial synaptic pruning is involved in the fear memory formation process, leading to development of abnormal stress-related behavior."

Science Up

New Science is Amazing & It has huge moral implications --- NOW

Transitional/ Translational Justice Monday

Building Individualized Supports For People with Neuro-Developmental Disorders & An IQ Over 70

Why is michael Marshall dead?

The Cellular basis of Neuro-Developmental & Psychiatric Disorders

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