"UNreasonable Fatigue" & Mitochondrial dysfunction in NEuro-Developmental & Psychiatric Disorders

​Val's Take/Conjecture

One of the amazing accomplishments of Modern psychiatric drugs of the past few decades --- they could resolve a psychosis in many cases.

Just get the medication right and add some Cognitive Behavioral Therapy (CBT) --- and you're good to go.

Well, sort of.

​It's been within the past 10 to 15 years that there has been a significant recognition that people with Neuro-Developmental and Psychiatric disorders have differences in EXECUTIVE FUNCTIONING.

It's been more recently that we are linking Executive Functioning challenges to Mitochondria Dysfunction and Microglia Dysregulation  -- dysregulation of the brain's innate immune cells.

This is not just Psychiatry or Neurology --- this is also Immunology (and other bodily systems and disciplines as well).

​Mitochondrial dysfunction in psychiatric disorders (2024)

Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain (2023)

​Mitochondrial dysfunction: A fatal blow in depression (2023)

​Associations of the immune system in aggression traits and the role of microglia as mediators (2024)

​Elena Carroll
What Autism Fatigue Really Looks Like in High Maskers

​"UNREASONABLE FATIGUE"

• More and more Neuro-Diverse youtubers are tackling the topics of FATIGUE and BURNOUT.
• Certainly, it looks like TIREDNESS, but it can also look like:
  • IRRITABILITY
  • PAIN --- maybe that associated with Migraines
  • Etc.

​Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)  (2023)

​Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression (2018)