The energy of anger & Aggression when mitochondria are damaged

Val's Take/Conjecture
Some of the questions that we are starting to ask:

• How much energy does it take to run a human brain?
• What are the big energy cost centers?   Synapses are arising as an answer.
• If you don't have the energy to run all your synapses --- does the body start taking care of that for you?  Reducing the number of synapses through auto-immunity or other mechanisms?
• Are Thyroid Disorders somehow related to these energy concerns?
• Does the body try to help you out with anger and aggression -- that might give you some much needed energy.
  

So this is painting a complicated picture of people who are struggling with both too little and too much energy.

That is explicitly recognized with regard to Bipolar Disorder and it may be present in other "disorders" as well, especially considering that they are often blurred.

Interestingly, a lot of the research regarding Mitochondrial Dysfunction speaks in terms of Mitochondrial Dysregulation.

I would submit that Mitochondrial Dysregulation is related to Emotional Dysregulation.

To see is to experience: Aggression neurons light up when witnessing a fight. (2023)

"In the current issue of Cell, Yang et al. identified hypothalamic aggression mirror neurons, activated during both physical fighting and witnessing a fight, possibly representing a neural mechanism for understanding social experiences in other minds...."

Powering the social brain: Mitochondria in social behaviour (2023)

"[W]e discuss recent evidence linking mitochondrial functions and dynamics to social behaviour and deficits, including examples in which social behaviours are modulated by stress in the context of mitochondrial changes, as well as potential therapeutic strategies and outstanding questions in the field."

I would submit that the relationship between "mitochondrial dysfunction" and "stress" is complex, dynamic and multi-directional (also including the Immune System, the Endocrine System, the Microbiome, etc.) and at least sometimes involves Maternal Immune Activation.

Topic: Aggressive Behaviors or Intense Energy?

Val's Take:  I don't think the question above should be posed as an "either or" question.

I think one could say the Aggressive Behaviors are the result of Intense Energy.

Where is the "Intense Energy" coming from?

ADHD Mood Swings: Symptoms, Causes, and Coping - Verywell Mind (2023)

"People with ADHD often find that their energy levels and ability to concentrate changes throughout the day. Even if they’re on medication, it can be difficult to match their high-energy and high-focus times to the times they need to be most productive. This can be upsetting and frustrating in the moment and cause mood swings."

Mitochondrial heterogeneity and homeostasis through the lens of a neuron (2022)

What are the implications for so-called "Aggression Neurons"?

8 Ways to Channel Your Anger Productively (2022) | Psych Central

Is anger energizing?

"This means anger is energizing. You can sit and seethe or work off your anger in a positive way. Rather than trying to remain calm, you could use your energy for tasks like cleaning, cutting the grass, or anything that requires physical involvement. Anger is an important human emotion."

I posted the  article from Psych Central because I think Anger can be Energizing -- the advice above might not always be sufficient.

Ultimately, anger is  a  complicated and difficult emotion as Aristotle recognized.  I think Aristotle probably was a "Neuro-Diverse" guy.