Mitochondrial Dysfunctionin neuro-Developmental & Psychiatric Disorders

​Val's Take/Conjecture

• When we think of "SUPPORTED EMPLOYMENT" we may think of someone with an IQ under 70 working at "menial work" that is often ESSENTIAL.
• For many people with Neuro-Developmental and Psychiatric Disorders --- they may have:
  • an average or above average IQ
  • expanded Sensory Processing, and
  • ​MITOCHONDRIAL DYSFUNCTION
  • ​The employment needs to ACCOMMODATE --- all 3 of those things.

Bob Dylan
The Times They Are A Changin'

​Mitochondrial dysfunction in psychiatric disorders (2024)

​Abstract

Psychiatric disorders are a heterogeneous group of mental disorders with abnormal mental or behavioral patterns, which severely distress or disable affected individuals and can have a grave socioeconomic burden.

Growing evidence indicates that mitochondrial function plays an important role in developing psychiatric disorders.

​This review discusses the neuropsychiatric consequences of mitochondrial abnormalities in both animal models and patients.

We also discuss recent studies associated with compromised mitochondrial function in various psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MD), and bipolar disorders (BD).

These studies employ various approaches including postmortem studies, imaging studies, genetic studies, and induced pluripotent stem cells (iPSCs) studies.

​We also summarize the evidence from animal models and clinical trials to support mitochondrial function as a potential therapeutic target to treat various psychiatric disorders.

​This review will contribute to furthering our understanding of the metabolic etiology of various psychiatric disorders, and help guide the development of optimal therapies.