Mitochondria dysfunction in Depression, Suicide, CANCER & Beyond

One of the things that Orchid is committed to is a "ROOT CAUSE ANALYSIS."

Much of the Neuro-Developmental / Psychiatric Continnuum appears to begin with Maternal Immune Activation and Mitochondrial Dysfunction ----

• and that in turn has many cascading effects over the lifespan.
• including dysfunction of mitochondria in T-Cells which appears to lead to greater deterioration that would generally be associated with age.

So there "may" be some pre-mature aging as the result of maternal immune activation..

Honing in on Mitochondria Dysfunction appears to be a key to Integrating Developmental, Physical and Mental Health.

Many physical health issues have psychiatric symptoms and many mental health issues do have physical symptoms.

Researchers around the world are focusing on Mitochondria.

Val's Tables

Mitochondrial Dysfunction:  A Fatal Blow in Depression  (2023)

Affiliations

• 1 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
• 2 Cancer Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
• 3 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China; Key Laboratory of Vascular Aging (HUST), Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Hubei, China.
  

The Significance of Mitochondrial Dysfunction in Cancer (2020)

"In most cells, mitochondria (green) form complex tubular networks that help them distribute energy throughout the cell. Disruption of these mitochondrial networks is a hallmark of many human diseases"

Blood Testing Identifies Biomarkers of Suicidal Thoughts (2023)

UC San Diego study

Naviaux Lab
 The story behind this is fascinating --- in seeking to address "orphan" mitochondrial diseases that affect few people, Naviaux Lab and others discovered that the problem of mitochondrial dysfunction was actually shared across many disease and disorder categories.