Inflammation, Positive "EMODIVERSITY" and CAUSE & EFFECT

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• Cause & Effect are complicated in Psychiatric Disorders
• Major Psychiatric Disorders are being linked to MATERNAL IMMUNE ACTIVATION and DEVELOPMENTAL INFLAMMATION
• "Positive Emodiversity" is interesting but is it a CAUSE or an EFFECT of LOWER INFLAMMATION​

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• Understanding CAUSE & EFFECT is a PROBLEM in our discussions of psychiatric disorders and it is definitely a problem in the Criminal Justice System.

• Now one of the reasons CAUSE and EFFECT are such a problem is because PSYCHIATRIC DISORDERS are not just GENETICS but the interplay of GENETICS, MATERNAL IMMUNE ACTIVATION, EPIGENETICS and ENVIRONMENT.

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• I would submit that people who were born with greater DEVELOPMENTAL INFLAMMATION probably are going to have a significantly harder time achieving the LOWER INFLAMMATION associated with "POSITIVE EMODIVERSITY."

Affiliations
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1Department of Human Development, Cornell University.
2Department of Human Development and Family Studies, The Pennsylvania State University.
3Department of Psychology, Arizona State University.

Epigenetics in Critical Illness:
A New Frontier (2013)

Emodiversity and biomarkers of inflammation (2018)

​Abstract

There is growing evidence that inflammatory responses may help to explain how emotions get “under the skin” to influence disease susceptibility.

Moving beyond examination of individuals’ average level of emotion, this study examined how the breadth and relative abundance of emotions that individuals experience— emodiversity—is related to systemic inflammation.

Using diary data from 175 adults aged 40 to 65 who provided end-of-day reports of their positive and negative emotions over 30 days, we found that greater diversity in day-to-day positive emotions was associated with lower circulating levels of inflammation (indicated by IL-6, CRP, fibrinogen), independent of mean levels of positive and negative emotions, body mass index, anti-inflammatory medications, medical conditions, personality, and demographics.

No significant associations were observed between global or negative emodiversity and inflammation.

These findings highlight the unique role daily positive emotions play in biological health.

IL-6 -- Interleukin-6 (CUSABIO)

Cytokine (Oxford Languages):  

1. any of a number of substances, such as interferon, interleukin, and growth factors, which are secreted by certain cells of the immune system and have an effect on other cells.

​Interleukin-6, also known as IL-6, is a cytokine that belongs to the class of interleukins.
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It is produced by fibroblasts, monocytes/macrophages, T lymphocytes, B lymphocytes, epithelial cells, keratinocytes, and various tumor cells.

The production of interleukin-6 can be induced in normal cells by various factors, involving IL-1, TNF-a, PDGF, viral infection, double-stranded RNA and so on.

For this reason, IL-6 plays a critical role in acute inflammatory response.

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​Mayo Clinic

The level of C-reactive protein (CRP) increases when there's inflammation in your body.

​ A simple blood test can be done to check your C-reactive protein level.

​Fibrinogen (Fg) is a biomarker of inflammation (1-5) which, when elevated, indicates the presence of inflammation and identifies individuals with a high risk for cardiovascular disorders.
Inflammatory Markers: Serum Amyloid A, Fibrinogen and C ...