Conjecture: Antibiotics, AlleRgies, Vaccines, Mitochondria & Catch-22s

Val's Take/Conjecture

• There were more people after the Black Death  that were subject to Auto-Immunity than before the Black Death (1346-1353).

Mother's autoimmune disease is associated with neuro-developmental & psychiatric disorders.

• Some autoimmune diseases more than others, Maternal Thyroid Disorders are particularly associated with neuro-developmental and psychiatric disorders.
  

Downs Syndrome is a neuro-developmental disorder and it is associated with pregnant women over 35, according to the Centers for Disease Control.

• Based on research from the University of Colorado, Down Syndrome is  more and more conceptualized as an Immune Disorder.
  • See also:  Immune Dysregulation in Down Syndrome [proposal that Down Syndrome is a "Cytokinopathy"]
    

Father's age is important as well:

• A 2019 study determined that a father's age has a significant impact on a child's health and development.
• The study found that babies born to older fathers had an increased risk of cleft lip or palate, heart defects, autism, schizophrenia and bipolar disorder.
  

www.nbcnews.com › health › parenting
Al Pacino expecting a baby at 83: Health risks for children ...

Antibiotic exposures and the development of pediatric autoimmune diseases: a register-based case–control study (2023)

Antimicrobial resistance (World Health Organization 2023)

Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod (2023)

Insights into new-onset autoimmune diseases after COVID-19 vaccination (China) (2023)

[V]accination implementation is critically significant.

However, growing evidence suggests that COVID-19 vaccination may cause new-onset autoimmune diseases, including autoimmune glomerulonephritis, autoimmune rheumatic diseases, and autoimmune hepatitis.

Nevertheless, the causal relationship between COVID-19 vaccines and these autoimmune diseases remains to be demonstrated.

In this review, we provide evidence that vaccination induces autoimmunity and summarize possible mechanisms of action, such as molecular mimicry, activation by bystanders, and adjuvants.

Our objective is not to refute the importance of vaccines, but to raise awareness about the potential risks of COVID-19 vaccination. In fact, we believe that the benefits of vaccination far outweigh the possible risks and encourage people to get vaccinated.

Our objective is not to refute the importance of vaccines, but to raise awareness about the potential risks of COVID-19 vaccination. In fact, we believe that the benefits of vaccination far outweigh the possible risks and encourage people to get vaccinated.

Potential health risks of mRNA-based vaccine therapy: A hypothesis (2023)

Susceptible individuals would then expectedly have an increased risk of DNA damage, chronic autoinflammation, autoimmunity and cancer.

In light of the current mass administration of nms-mRNA vaccines, it is essential and urgent to fully understand the intracellular cascades initiated by cellular uptake of synthetic mRNA and the consequences of these molecular events.

How the Black Death shaped human evolution

• Another protective variant has been associated with an increased risk of two autoimmune diseases. Thus, the Black Death and other past pandemics may have shaped humans’ immune systems in ways both good and bad.
  

While we acquired better protection against infections, we became more susceptible to autoimmune diseases.

Long-term risk of autoimmune diseases after mRNA-based SARS-CoV2 vaccination in a Korean, nationwide, population-based cohort study  (Korea) (2024)

We report that the risk of developing most AI-CTDs  [autoimmune connective tissue diseases] did not increase following mRNA vaccination, except for systemic lupus erythematosus with a 1.16-fold risk in vaccinated individuals relative to controls.

Comparable results were reported in the stratified analyses for age, sex, mRNA vaccine type, and prior history of non-mRNA vaccination.

However, a booster vaccination was associated with an increased risk of some AI-CTDs [autoimmune connective tissue diseases] including alopecia areata, psoriasis, and rheumatoid arthritis.

Overall, we conclude that mRNA-based vaccinations are not associated with an increased risk of most AI-CTDs, although further research is needed regarding its potential association with certain conditions.

Val's Take:      The discussion on vaccines is becoming more sophisticated.

I'm not for banning antibiotics or vaccines, but I do think there are issues, especially over time.