Autoimmunity and: Neuro-Developmental Disorders, Cancer, Psychiatric Disorders & Dementia

Val's Note:  The focus here is on "Auto-Immunity" and there seem to be numerous associations in areas we might not expect; although more and more we might expect them.

Beyond "Auto-Immunity" there often seem to be "Immune Mechanisms" that are important, this may be true in "Depression" where the evidence for classic "Auto-Immunity" is conflicting but nonetheless seems clear that "Immune Mechanisms" are relevant.

Additionally, it appears that "Immune Mechanisms" are relevant with regard to Substance Use Issues.

Autoimmunity and Cancer-Two Sides of the Same Coin (2022)

Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases (2022)

Affiliations

• 1 Broad Institute of the Massachusetts Institute of Technology and Harvard University, The Klarman Cell Observatory, Cambridge, MA, USA.
• 2 Department of Epidemiology and Public Health, University College London, London, UK.
• 3 Clinicum, Department of Public Health, University of Helsinki, Helsinki, Finland.
• 4 Broad Institute of the Massachusetts Institute of Technology and Harvard University, The Klarman Cell Observatory, Cambridge, MA, USA.
• 5 Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
• 6 Clinicum, Department of Public Health, University of Helsinki, Helsinki, Finland.
• 7 Department of Epidemiology and Public Health, University College London, London, UK.
• 8 Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.
• 9 Research & Development, Biogen Inc., Cambridge, MA, USA.
• 10 Division of Psychiatry, University College London, London, UK.
• 11 Camden and Islington NHS Foundation Trust, London, UK.
• 12 Glenn Biggs Institute of Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.
• 13 Boston University School of Public Health, Boston, MA, USA.
• 14 New York University Grossman School of Medicine, New York, NY, USA.
• 15 Boston University School of Medicine, Boston, MA, USA.
• 16 Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• 17 Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• 18 Institute of Cardiovascular Science, University College London, London, UK.
• 19 University College London, British Heart Foundation Research Accelerator, London, UK.
• 20 Health Data Research UK, London, UK.
  

National Institute of Health
Harnessing the Immune System to Protect Against Opioid Addiction and Overdose (2023)

Medical Dialogues
Hidden Mental Health Symptoms in People Living with Long Term Autoimmune Disease

Role of autoimmunity in Neuronal damage in children with Autism spectrum disorder (2023)

Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin (2020)

Association of Maternal Autoimmune Disease With Attention-Deficit/Hyperactivity Disorder in Children (2021)

Schizophrenia as autoimmune disease: Involvement of Anti-NCAM antibodies (2023)

The prevalence of bipolar disorder in autoimmune disease: a systematic review and meta-analysis (2021)

Conclusions:

The prevalence of bipolar disorder is markedly higher in patients with autoimmune disease.

Yet, more basic research is needed to verify the special significance of immune mechanisms in bipolar disorder. 

Subclinical thyroid dysfunction and major depressive disorder (2021)

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression (2022)

Microglia are the predominant resident immune cells in the brain and exhibit a critical role in depression.

Val's Take:   Autoimmunity and various Immune Mechanisms are extremely important for understanding human cognition and behavior, the neuro-developmental/psychiatric continuum and relationships to other chronic diseases.

***Physical Health Issues, the Immune System & Mental Health