Inflammation, Fatigue, Aggression and Neuro-Diversity

Val's Take/Conjecture

• FATIGUE is a driving issue in many Neuro-Diverse challenges.
• We are starting to recognize the association between Neuro-Diversity and other disorders and diseases involving fatigue such as:
  • ME/CFS (Chronic Fatigue Syndrome),
  • Fibromyalgia
  • Multiple Sclerosis 
  • Hyper-Mobility Syndromes
  • etc.
• The disorders listed above tend to hit women much harder than men, although there are exceptions.

When it comes to some Neuro-Diverse men and energy and aggression, the conversation is complicated.

It's not that women aren't using AGGRESSION as well to gin their energy up, but they may not be getting away with it and even women who are getting away with it---

• those women are not likely to be as physically aggressive.

So when someone like Elon Musk says --- "Hey, I'm this high energy, aggressive Neuro-Diverse guy"

• Yeah, but
• You wouldn't be so aggressive, if you had the energy not to be.

Further, the aggression doesn't create energy, it mobilizes what energy is there by the release of stress hormones.

Prolonged exertion of self-control causes increased sleep-like frontal brain activity and changes in aggressivity and punishment (2024)

Childhood neurodivergent traits, inflammation and chronic disabling fatigue in adolescence: a longitudinal case–control study  (2024) ​

​Conclusions:  Our results indicate higher risk of chronic disabling fatigue for children with neurodivergent traits, likely linked to higher levels of inflammation. The implementation of transdiagnostic screening criteria to inform support strategies to counteract risk early in life is recommended.

​Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression (2024)

All adolescents need support making the transition to Adulthood, and Neuro-Diverse kids with an IQ over 70 need support in order to avoid Homelessness or Criminal Justice involvement.

That "Executive Functioning" from ages 4-6 may undergo previously unpredicted upheavals due to complex dysregulations of the brain's immune cells, among many other things.