Contrasting these results, whole brain and right hemispheric networks of GTS patients showed significantly increased normalized global efficiency indicating an overall increase of structural integration among distributed areas.

Higher global efficiency was associated with tic severity (R = 0.63, p = 0.022) suggesting the clinical relevance of altered network topology.

Our findings reflect an imbalance between structural integration and segregation in right hemispheric structural connectome of patients with GTS.

These changes might be related to an underlying pathology of impaired neuronal development, but could also indicate potential adaptive plasticity.

According to Dr. Meglathery, those with the CAPS profile are
at higher risk of chronic illness, especially when an individual
has inherited two copies of CYP21A2 mutations, one from
each parent.

The crux of the CAPS profile is a brain wired for survival--the ability to move fast, the ability to get into flow, the ability to really push oneself, all of which are what we in the gifted community view as overexcitabilities.

Dr. Meglathery’s description of a brain with CAPS echoes familiar refrains from the gifted literature: “[The CAPS brain] is characterized by an exaggerated stress response, sensory
sensitivities, hyper-focus, strong special interests, often mental gifts paired with learning disabilities/Asperger’s, an  androgenized brain.”

-----page 8-9.