Cancer & Neuro-Diversity --- The Crying Need for Accelerating Integrated Physical & Mental Health Care

Frontiers in Cell & Developmental Biology (2021)
The Role of Neurodevelopmental Pathways in Brain Tumors

So one of the BIG PROBLEMS with the DSM 5 SYMPTOM CLUSTERS is it MISSES COMMON SYSTEMIC INFLAMMATION and GENES across DISORDERS.

So people are NOT NEATLY PATTERN MAPPING to these SYMPTOM CLUSTERS and there is a lot of LATE DIAGNOSIS and EMERGENCIES and CRISES.

Further --- people are "MASKING" generally for as long as they can --- so by the time some of these issues come to light --- the person may be pretty far down the road of psychiatric illness.

Beyond that people with PSYCHIATRIC ISSUES often have ONE or MORE PSYCHIATRIC CO-MORBIDITIES --- BUT they also may have PHYSICAL HEALTH CO-MORBIDITIES that in one way or another are related to this NEURO-DEVELOPMENTAL INFLAMMATION.

To really appreciate the DYNAMICS in most parts of the world --- you need to understand that most MODERN POPULATIONS have LOW GRADE INFLAMMATION and 1/4 to 1/5 of those populations have some type of psychiatric issue.

Further, autoimmune disease is rampant as are Cancer and other Inflammatory Diseases.

This is where we need PRECISION MEDICINE because this INFLAMMATION does affect us quite INDIVIDUALLY.  

The Impact of Systemic Inflammation on Neurodevelopment  https://www.ncbi.nlm.nih.gov › articles › PMC6110951

by NM Jiang · 2018 · Cited by 114 -- Several neurodevelopmental disorders have been linked to early life immune activation and inflammation, including autism spectrum disorders (ASD) ...
Ascending infection: infection during pregnancy ...
Hypothalamic-pituitary-adrenal (HPA) axis: set .

Cancer and systemic inflammation: treat the tumour ... - NCBIhttps://www.ncbi.nlm.nih.gov › articles › PMC3960633

by CSD Roxburgh · 2014 · Cited by 293 -- Relationship between systemic inflammatory response, symptom clusters and survival ... Symptoms associated with cancer are commonly regarded as natural sequelae ...
‎Measurement of the systemic... · ‎Relationship between... · ‎Treatment of cancer...

The curious connection between autism and cancer | Spectrum  https://www.spectrumnews.org › features › deep-dive

Jan 11, 2017 -- The growing number of cancer genes linked to autism piqued the curiosity of Janine LaSalle, an autism researcher at the University of California ...

Autism and Cancer - EKU Onlinehttps://ekuonline.eku.edu › blog › psychology › autism...

Apr 7, 2021 — While autism spectrum disorder and cancer may appear entirely unrelated, there is actually a significant amount of overlap within the ...

Is there a Genetic Link between Autism and Cancer? https://www.cancersupportcommunity.org › 2017/04

Apr 12, 2017 — Dozens of genes have been linked to both autism and cancer. ... neck, thyroid, prostate, skin, breast, and lung cancer, and much more.

Subsequently Added:

Karlinska Institutet in Sweden

New study shows antioxidants stimulate blood flow in tumors

August 23, 2023

"Vitamin C and other antioxidants stimulate the formation of new blood vessels in lung cancer tumors, a new study from Karolinska Institutet published in the Journal of Clinical Investigation shows.

"The discovery corroborates the idea that dietary supplements containing antioxidants can accelerate tumor growth and metastasis."

Someone like myself who is very short ---- might have a lot of SYSTEMIC INFLAMMATION but there does seem to be something that is PROTECTIVE about SHORT STATURE when it comes to CANCER and even DIABETES.

Summary: A long-term study finds extremely low incidence of cancer and diabetes among individuals with a growth-stunting genetic defect. The authors ask whether controlling growth hormone in healthy adults might provide similar protection.  Feb 16, 2011

Dwarfism gene linked to protection from cancer and diabetes

On the other hand, I haven't been protected from Neuro-Developmental Disorders, Psychiatric Disorders, Thyroid Disease and Osteoporosis.

Petite and thin women have a greater chance of developing osteoporosis. One reason is that they have less bone to lose than women with more body weight and larger frames. Similarly, small-boned, thin men are at greater risk than men with larger frames and more body weight. Broken bones. Jul 30, 2021

Osteoporosis: Are You at Risk? - WebMD

(I'm NOT thin, BUT I am SHORT)

Someone like my husband who recently passed away from LUNG CANCER ---

• NEVER Smoked
• Was 5'11"
• had a mother with Bipolar Disorder
• Given my mother-in-law's history of psychiatric illness, I think it likely that Rick was born with significant NEURO-DEVELOPMENTAL INFLAMMATION
• I would say he was quite BRILLIANT --- he would not trust that as EXAGGERATION
• Had a lot of ANXIETY
• Surprisingly had issues with CHRONIC DISORGANIZATION.
• Was probably exposed to RADON in the family home in Colorado as a child in the 1950s and 1960s.
• RADON EXPOSURE is the leading cause of non-smoking lung cancer.
• I think the possibility that Rick already had significant NEURO-DEVELOPMENTAL INFLAMMATION "may" have made him MORE VULNERABLE to a DEADLY DISEASE ---- he and his family didn't think he had to worry about because he didn't smoke.
  

Although calcium signal remodeling involves changes of different Ca2+-permeable channels, Ca2+ entry through ORAI channels is particularly important, as its dysregulation contribute to cancer features such as sustained proliferation, apoptosis resistance and invasion.Jul 7, 2020

Calcium Permeable Channels in Cancer Hallmarks - Frontiers

NIMH:  ADHD, Autism,  Bipolar Disorder , Depression & Schizophrenia Share Problems with Calcium Channels (2013)

Clinical features and diagnosis of psychiatric disorders in ...
https://www.uptodate.com › contents › clinical-features-an...

by J Rivest · Cited by 1 -- Patients with cancer have a high rate of comorbid psychiatric disorders as well as nonspecific psychological distress .