ADHD, Autism, Bipolar Disorder, Depression & Schizophrenia As Multi-System Disorders

​Val's Take/Conjecture

• This view of Neuro-Developmental and Psychiatric Disorders as multi-system conditions is relatively new and has many ramifications.
• In addition, Neuro-Degenerative Disorders such as Parkinson's, Huntington's Disease and Alzheimer's are now viewed as multi-system disorders.

What are the ramifications of Neuro-Developmental & Psychiatric Disorders as Multi-System Disorders?

• For Treatment
• For Criminal Justice Involvement
• and Homelessness 

​If we don't know, who bears the burden?

Burden of Proof

Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework (2024)

 "Mounting evidence from a variety of transcriptomic, proteomic, metabolomics and brain imaging studies points toward the possibility that schizophrenia is a systemic disorder and involves abnormal glucose and energy metabolism both in the periphery and in brain."

​Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling (2016)

Psychoneuroimmunology of Mood Disorders (2025)

​Abstract

Recent research has shed light on the intricate relationship between mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD), and inflammation.

This chapter explores the complex interplay involving immune and metabolic dysfunction in the pathophysiology of these disorders, emphasizing their association with autoimmunity/inflammatory conditions, chronic low-grade systemic inflammation, T cell overactivation, and immunosenescence.

​This perspective underscores the notion that MDD [Major Depressive Disorder] and BD [Bipolar Disorder] are not solely brain disorders, highlighting their nature as multi-system conditions.

​ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications (2016)