WE NEED a "NaRRATIVE" that hangs together when it comes to the Neuro-developmental - Psychiatric ContinuumThat could vastly improve Public Policy & Justice

Kurt Vonnegut --- "Cat's Cradle"

Val's Take/Conjecture

• There is A LOT to weave together when it comes to understanding the Neuro-Developmental-Psychiatric Continuum and it's relationship to other disorders.
• The DOMINANT PARADIGM of the last 60 years --- "JUST TAKE THE DAMN MEDICATION" --- probably averted some tragedies and created others.
• When we see a bunch of people lying on the street --- one idea is that "THEY'RE JUST LAZY."
• Another possibility is some of them have serious METABOLIC DISORDERS that involve the brain and it's ability to produce ATP to run not only the brain but the rest of the body, including the ENDOCRINE SYSTEM.

• People subject to MATERNAL IMMUNE ACTIVATION during their own time in the womb tend to have "HYPER-CONNECTED BRAINS."
• I would submit that "HYPER-CONNECTED BRAINS" require more ATP to operate.
  

One of the things that some studies are pondering are the GENERATIONAL ASPECTS to MATERNAL IMMUNE ACTIVATION.

We live in such an INDIVIDUALISTIC CULTURE that CONNECTIONS to the BROADER WORLD are often DENIED --- sometimes out of PRACTICALITY we don't have the BANDWIDTH to consider it.

• BUT what this often looks like is a BIG MORAL JUDGMENT coming down on the INDIVIDUAL.

It's probably no accident that the DEADLIEST Psychiatric Disorders are EATING DISORDERS.

One of the challenges, probably not the only challenge, is to make KETOGENIC DIETS --- HEART HEALTHY.

We did go through a period of LOW FAT, HIGH SUGAR that was pretty DISASTROUS in the weight-loss market.

I think more and more people recognize the problem of sugar but CAFFIENATED DRINKS and ENERGY DRINKS --- that market is HUGE ---- and I would submit it is because many people don't have the ENERGY to get through the day and they are looking for a QUICK FIX.

• The effect of caffeine is related to its structural similarity to adenosine. Adenosine is a nucleotide and is important for coding genes, but it is also used for energy in the form of ATP and as a neuromodulator and signaling molecule. When the brain is active, it consumes lots of ATP (adenosine triphosphate) as an energy source.

Reference: Caffeine: How it works and myths surrounding it - Chemistry ...

Sleep Foundation:  Caffeine and Sleep

Key Takeaways

• Caffeine promotes wakefulness by blocking adenosine, a sleep-inducing chemical.
• Sensitivity to caffeine varies among individuals and depends on how often it is consumed.
• Avoid caffeine at least 8 hours before bedtime to ensure better sleep quality.
• Reduce your daily caffeine intake if you notice insomnia, anxiety, or headaches impacting your ability to sleep.

Unfortunately, even DIET SODAS are bad for our TEETH and if it's BAD for our TEETH --- it's generally bad for our PHYSICAL & MENTAL HEALTH.

I have started to include MORE FAT in my diet and the effects were pretty DRAMATIC --- I seemed to not only need less LITHIUM, but also LESS DIET COKE.

I think if people have HEALTHY WAYS to MANAGE their BIOLOGY --- They'll DO IT.

BUT TRUTH is the Medical Professional has been all over the map the past few decades regarding diet advice and some of it was TRULY CATASTROPHICALLY UNHEALTHY.

AND for those people who DON'T LOOK LIKE they have SPECIAL NEEDS --- BUT DO ---

YOU MY FRIEND ARE AT VERY HIGH RISK.

Wilma Mankiller --- 1st Female Chief of the Cherokee Nation

Transgenerational Effects of Maternal Immune Activation on Specific Antibody Responses in Layer Chickens.

Verwoolde MB, Arts J, Jansen CA, Parmentier HK, Lammers A. Front Vet Sci. 2022 Feb 17;9:832130. doi: 10.3389/fvets.2022.832130. eCollection 2022. PMID: 35252424 Free PMC article.

Activation of the maternal immune system may affect innate and adaptive immune responses in the next generation and may therefore have implications for vaccine efficacy and dietary immune modulation by feed additives. ...Furthermore, our …

Maternal immune activation transgenerationally modulates maternal care and offspring depression-like behavior.

Ronovsky M, Berger S, Zambon A, Reisinger SN, Horvath O, Pollak A, Lindtner C, Berger A, Pollak DD. Brain Behav Immun. 2017 Jul;63:127-136. doi: 10.1016/j.bbi.2016.10.016. Epub 2016 Oct 17. PMID: 27765645 Free article.

Gestational infection is increasingly being recognized for its involvement as causative mechanism in severe developmental brain abnormalities and its contribution to the pathogenesis of psychopathologies later in life. First observations in the widely accepted maternal …

Transgenerational Sex-dependent Disruption of Dopamine Function Induced by Maternal Immune Activation.

Santoni M, Frau R, Pistis M. Front Pharmacol. 2022 Feb 8;13:821498. doi: 10.3389/fphar.2022.821498. eCollection 2022. PMID: 35211019 Free PMC article.

Mounting evidence supports the hypothesis that detrimental effects of maternal immune activation might be transmitted across generations. ...These results confirm that maternal immune activation negatively influences, in a sex-depe …

At the end of the day, WE DON'T HAVE THIS FIGURED OUT we're figuring it out.

That matters when it comes to JUSTICE and BURDEN of PROOF

Burden of Proof