Neurology Advisor
Pediatric Ischemic Stroke Tied to ADHD

Stroke & ADHD
(and Psychotic Disorders)

Observational studies have found an association between attention-deficit/hyperactivity disorder (ADHD) and ischemic stroke.

Conclusions:  Genetic liability to ADHD was significantly associated with an increased risk of AIS [Arterial Ischemic Stroke], especially LAS [Large-Artery Atherosclerotic Stroke].

Majority of Stroke Patients May Have Undiagnosed Attention Issues

Dilemma of Treating Psychosis Secondary to Stroke

Psychotic Disorders and the Neurodevelopmental Continuum

Posttraumatic Stress Disorder and Risk for Stroke in Young and Middle-Aged Adults

Potential Mechanisms Linking PTSD and Stroke in the Young

Although the mechanisms linking PTSD to incident stroke are not fully understood, multiple pathways are possible.

Prolonged exposure to intense psychological stress is associated chronic inflammation, endothelial dysfunction, platelet activation and aggregation, and autonomic dysregulation, all of which could conceivably contribute to atherothrombotic manifestations.

Stress is also associated with a greater likelihood of smoking, physical inactivity, poor diet, and substance abuse, which may increase risk for early stroke.

However, we controlled for most of these lifestyle behaviors, and the findings were largely maintained.

Other relevant health factors such as sleep disturbance, migraine, and periodontal disease have been shown to increase risk of stroke in the young.

Evaluating the complex interplay between these health factors, PTSD and stroke in young adults is an important area for further research.