A hodgepodge of thoughtS, Studies & concerns
Neuro-developmental Inflammation and Metabolic Dysregulation
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Val's Take If we solve the "Mental Illness" puzzle we will likely solve the Obesity Epidemic. 
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways (2016)
Abstract The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial functions. Our appreciation of the importance of these microbial communities to many aspects of human physiology has grown dramatically in recent years. We know, for example, that animals raised in a germ-free environment exhibit substantially altered immune and metabolic function, while the disruption of commensal microbiota in humans is associated with the development of a growing number of diseases. Evidence is now emerging that, through interactions with the gut-brain axis, the bidirectional communication system between the central nervous system and the gastrointestinal tract, the gut microbiome can also influence neural development, cognition and behaviour, with recent evidence that changes in behaviour alter gut microbiota composition, while modifications of the microbiome can induce depressive-like behaviours. Although an association between enteropathy and certain psychiatric conditions has long been recognized, it now appears that gut microbes represent direct mediators of psychopathology. Here, we examine roles of gut microbiome in shaping brain development and neurological function, and the mechanisms by which it can contribute to mental illness. Further, we discuss how the insight provided by this new and exciting field of research can inform care and provide a basis for the design of novel, microbiota-targeted, therapies. 
Abstract The wealth of recent evidence about a bi-directional communication between nerve- and immune- cells revolutionized the traditional concept about the brain as an "immune-privileged" organ while opening novel avenues in the pathophysiology of CNS disorders. In fact, altered communication between the immune and nervous system is emerging as a common hallmark in neuro-developmental, neurodegenerative, and neuro-immunological diseases. At molecular level, the ubiquitin proteasome machinery operates as a sentinel at the crossroad between the immune system and brain. In fact, the standard proteasome and its alternative/inducible counterpart, the immunoproteasome, operate dynamically and coordinately in both nerve- and immune- cells to modulate neurotransmission, oxidative/inflammatory stress response, and immunity. When dysregulations of the proteasome system occur, altered amounts of standard- vs. immune-proteasome subtypes translate into altered communication between neurons, glia, and immune cells. This contributes to neuro-inflammatory pathology in a variety of neurological disorders encompassing Parkinson's, Alzheimer's, and Huntingtin's diseases, brain trauma, epilepsy, and Multiple Sclerosis. In the present review, we analyze those proteasome-dependent molecular interactions which sustain communication between neurons, glia, and brain circulating T-lymphocytes both in baseline and pathological conditions. The evidence here discussed converges in that upregulation of immunoproteasome to the detriment of the standard proteasome, is commonly implicated in the inflammatory- and immune- biology of neurodegeneration. These concepts may foster additional studies investigating the role of immunoproteasome as a potential target in neurodegenerative and neuro-immunological disorders. We think Diet & Exercise are important. But we don't want a situation in which other important factors are not considered as well.
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Greg Doucette (Feb. 2020)
Metabolism Doesn't Matter - Why Having A Fast Or Slow Metabolism Does NOT Determine Your Body Fat ----Your Ability to Suffer Matters, TRAIN HARDER The over-the-top and very fun Greg Doucette probably does have a lot to teach us --- BUT it certainly appears there's even more to the story.
There are some professionals that are not that far from Greg Doucette and that's really a problem because ---
BUT SEE:
Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation (2019)
Abstract Abnormal behaviors in individuals with neurodevelopmental disorders are generally believed to be irreversible. Here, we show that voluntary wheel running ameliorates the abnormalities in sociability, repetitiveness, and anxiety observed in a mouse model of a neurodevelopmental disorder induced by maternal immune activation (MIA). Exercise activates a portion of dentate granule cells, normalizing the density of hippocampal CA3 synapses, which is excessive in the MIA-affected offspring. The synaptic surplus in the MIA offspring is induced by deficits in synapse engulfment by microglia, which is normalized by exercise through microglial activation. Finally, chemogenetically induced activation of granule cells promotes the engulfment of CA3 synapses. Thus, our study proposes a role of voluntary exercise in the modulation of behavioral and synaptic abnormalities in neurodevelopmental disorders. Mixed Bags & the Proof is In the Pudding
I think all these things can "HELP" and should be explored. At the end of the day, some of us are STILL NOT NEURO-TYPICAL & our METABOLISM's aren't TYPICAL either--- and there has to be SPACE to say that. NOT just WORK HARDER. [In fairness, Greg Doucette might not recognize the problem of a slow metabolism as any real barrier to weight loss, but he does note the problem of "Sh---tty Genes."] The more we understand Mental Health and Metabolic Dysregulation through a PRECISION MEDICINE PERSPECTIVE --- the better off a lot of us are going to be. |