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Intergenerational trauma Research

​Biological pathways for historical trauma to affect health:     A conceptual model focusing on epigenetic modifications.

Conching AKS, Thayer Z. Soc Sci Med. 2019 Jun;230:74-82. doi: 10.1016/j.socscimed.2019.04.001. Epub 2019 Apr 5.PMID: 30986608

The first pathway suggests that personal exposure to trauma or stressors, which are more common among populations that have experienced historical trauma, can induce epigenetic modifications that can contribute to the development of poor health. The se …
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Affiliations

• 1406A Silsby, Dartmouth College, Hanover, NH, 03755, United States. Electronic address: andie.conching@gmail.com.
• 2406A Silsby, Dartmouth College, Hanover, NH, 03755, United States. Electronic address: Zaneta.marie.thayer@dartmouth.edu.

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.

Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB.  Biol Psychiatry. 2016 Sep 1;80(5):372-80. doi: 10.1016/j.biopsych.2015.08.005. Epub 2015 Aug 12.PMID: 26410355

​BACKGROUND: The involvement of epigenetic mechanisms in intergenerational transmission of stress effects has been demonstrated in animals but not in humans. ...CONCLUSIONS: This is the first demonstration of an association of preconception parental trauma with epige …

Affiliations

• 1Traumatic Stress Studies Division, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; Mental Health Care Center, PTSD Clinical Research Program & Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J. Peters Veterans Affairs Medical Center, Bronx, New York. Electronic address: rachel.yehuda@va.gov.
• 2Traumatic Stress Studies Division, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; Mental Health Care Center, PTSD Clinical Research Program & Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J. Peters Veterans Affairs Medical Center, Bronx, New York.
• 3Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
• 4Max Planck Institute of Psychiatry, Munich, Germany; HMNC Holding GmbH, Munich, Germany.

​Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms.


Yehuda R, Lehrner A.  World Psychiatry. 2018 Oct;17(3):243-257. doi: 10.1002/wps.20568.PMID: 30192087 Free PMC article.

This paper reviews the research evidence concerning the intergenerational transmission of trauma effects and the possible role of epigenetic mechanisms in this transmission. ...Several factors, such as sex-specific epigenetic effects following traum …

Affiliations

• 1James J. Peters Bronx Veterans Affairs Hospital, Bronx, NY, USA.
• 2Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Transgenerational Epigenetics of Traumatic Stress.

Jawaid A, Roszkowski M, Mansuy IM. Prog Mol Biol Transl Sci. 2018;158:273-298. doi: 10.1016/bs.pmbts.2018.03.003. Epub 2018 Jun 11.PMID: 30072057 Review.

This book chapter discusses the concept of epigenetic/non-genomic inheritance of such traits involving the germline in mammals. It includes a comprehensive review of animal and human studies on inter- and transgenerational inheritance of the effects of traumatic stress, so …

Affiliations

• 1Laboratory of Neuroepigenetics, Medical Faculty of the University of Zurich and Department of Health Science and Technology of the Swiss Federal Institute of Technology, Neuroscience Center Zurich, Zurich, Switzerland.
• 2Laboratory of Neuroepigenetics, Medical Faculty of the University of Zurich and Department of Health Science and Technology of the Swiss Federal Institute of Technology, Neuroscience Center Zurich, Zurich, Switzerland. Electronic address: mansuy@hifo.uzh.ch.